Abstract Search

ba0003pp316 | Osteoporosis: treatment | ECTS2014

Odanacatib treatment improves lumbar vertebral bone mineral density and strength in orchiectomized rabbits

Duong Le T , Chen Charles , Pennypacker Brenda L

The selective cathepsin K inhibitor odanacatib (ODN) is currently in development for the treatment of postmenopausal osteoporosis. Our goal was to evaluate the effects of ODN vs alendronate (ALN) on bone mass and strength of lumbar vertebrae (LV) in orchiectomized (ORX) rabbits, a model of male osteoporosis. Adult male rabbits (11 months old) were subjected to sham- (n=20) or ORX-surgery (n=24/group) for 7.5 months before dosing initiated. ORX animals were ra...

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ba0003pp27 | Bone biomechanics and quality | ECTS2014

Long term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT based finite element analysis of the vertebral cores

Cabal Antonio , Jayakar Richa Y , Zhang Jingru , Sardesai Swanand , Williams Donald S , Duong Le T

The cathepsin K inhibitor odanacatib (ODN) is a bone formation-sparing inhibitor of osteoclastic resorption activity. This drug is currently under development for the treatment of postmenopausal osteoporosis. To support the bone safety profile of ODN, we evaluated the effects of ODN on trabecular bone hard tissue properties in the estrogen-deficient model of the ovariectomized (OVX) rhesus monkeys. Animals (n=16/group, age 1122 years) were treated immediately af...

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Bone Abstracts

Odanacatib treatment improves lumbar vertebral bone mineral density and strength in orchiectomized rabbits

Long term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT based finite element analysis of the vertebral cores

BiosciAbstracts